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Time called on chimp work

March 19, 2013 This article courtesy of Nature News.

NIH likely to retire hundreds of government-owned chimpanzees.

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Government-funded chimpanzee research in the United States has been on notice for more than a year. This month, its time is probably up.

First came a report from the Institute of Medicine (IOM) in December 2011, which found that most chimp research is unnecessary, given that almost all questions can be explored in other animal models or in vitro.

Now Francis Collins, director of the National Institutes of Health (NIH), is expected to accept the bulk of the recommendations from an NIH working group that would retire several hundred agency-owned chimpanzees, leaving a core of just 50 animals available for NIH research. The working group, which on 22 January released proposals for how the NIH should implement the IOM report, also said that the agency should end six of the nine invasive studies that it funds. And the other three would be allowed to continue only if the animals’ environments are substantially improved, probably at great expense.

Should Collins accept the recommendations, it would be “a milestone in animal-research practice and policy, and an endorsement of the conclusion that there is a rapidly decreasing need for the use of chimpanzees in research”, says Jeffrey Kahn, a bioethicist at Johns Hopkins University in Baltimore, Mary­land, who led the 2011 IOM committee.

The working group did not identify which experiments it thought should end, so NIH researchers will learn the fate of their studies only after Collins’s decision. Several chimpanzee researchers contacted by Nature declined to speak on the record about their work, but some lamented that unique science would disappear.

The nine invasive biomedical experiments include one that is searching for an infectious trigger for primary biliary cirrhosis, a disease that slowly destroys the liver and is fatal without a transplant. Another, conducted by a biotechnology company, tests an agent that binds to molecular targets on immune cells and is intended to shut down the immune response that causes diseases such as rheumatoid arthritis and lupus. The candidate drug’s targets occur in only two species: humans — in whom safety tests of the compound would be ethically impermissible — and chimpanzees. If the study is killed, “this line of investigation will probably have to stop”, says one observer with knowledge of the study.

Although the IOM committee was unanimous in declaring chimpanzees unnecessary for almost all invasive research, it was split on whether the animal is essential for developing a vaccine against hepatitis C, which kills some 350,000 people globally each year. The chimpanzee is the only animal model that can test whether an immune response to a candidate vaccine would protect against hepatitis C infection. One of the nine studies now in jeopardy explores why the immune response in chimpanzees often cannot clear hepatitis C infections.

“Everybody working with chimpanzees in the hepatitis C field realizes that they are really unique animals,” says Stanley Lemon, who studies hepatitis C at the University of North Carolina, Chapel Hill, and who resigned from the NIH working group last year. “But you have to balance that against the weight of human morbidity and mortality.”

The working group also recommended that five of 13 behavioural and comparative-genomics studies should end. The Yerkes National Primate Research Center in Atlanta, Georgia, hosts some of these studies, which include an assessment of the roles of the hormones vasopressin and oxytocin in social cognition, and a look at how genes and early social experiences affect brain development and behaviour.

Even if Collins allows the Yerkes studies to continue, the recommendation for new housing requirements could doom the projects. The working group proposed the provision of 6.1 vertical metres of climbing structure and 93 square metres of space for each animal; fresh mater­ials for daily construction of nests; foraging opportunities; and housing in social groups of at least seven. “We estimate it could cost tens of millions of dollars for our centre alone to renovate space that will have limited use given our ageing colony,” says Yerkes spokeswoman Lisa Newbern.

Some ethicists say that if Collins embraces the recommendations, his decision will not only mark the end of most government-supported chimpanzee research, but also raise questions about work on other non-human primates. The NIH supports a network of primate research centres that houses some 27,000 non-human primates of 20 species. “We’re not going to suddenly decide that all primates have got to be retired,” says Gregory Kaebnick, a research scholar at the Hastings Center in Garrison, New York, who last month led a study on changing ethical views on animal research. “But we might find ourselves trying to reassess the way we’ve been using them.”

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