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Fossil Fuels and the Carbon Cycle

Author(s): David R. Caprette, PhD
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Gene Expression and Supplement Intake Related to Colon Cancer

When we looked at specific genes either up- or down-regulated as a function of diet, radiation, or time, the importance of monitoring these changes over time became apparent. This slide shows the expression of one gene over time (interleukin 1 beta-a pro-inflammatory protein that promotes colon cancer). If we ask, "What is the effect of diet on the expression of interleukin 1 beta?" the answer is, "It depends." As depicted in the graph, at the earliest time point (week 7), gene expression is higher in rats fed fish oil. At 15 weeks, expression levels are the same for both diets, and at the final tumor endpoint (30 weeks), the corn oil/cellulose diet resulted in much higher expression levels than did the fish oil/pectin diet. This finding emphasizes the point that if one monitors the effect of diet on gene expression, it is more accurate to do so in a time-dependent manner than as a single snapshot.

To summarize the studies on diet and radiation-enhanced colon cancer: a diet high in fish oil and pectin can protect against radiation-enhanced colon cancer and a noninvasive technique can be used to monitor colon gene expression over time.

Funded by the following grant(s)

National Institute of Environmental Health Sciences, NIH

National Institute of Environmental Health Sciences, NIH

My Health My World: National Dissemination
Grant Number: 5R25ES009259
The Environment as a Context for Opportunities in Schools
Grant Number: 5R25ES010698, R25ES06932

Houston Endowment Inc.

Foundations for the Future: Capitalizing on Technology to Promote Equity, Access and Quality in Elementary Science Education