Type 1 Diabetes Mellitus
This diagram shows where in the glucose metabolic pathway Type 1 diabetics differ from healthy individuals.
Type 1 diabetes is an autoimmune disorder, meaning the body's immune system is not functioning properly and attacks the body itself. In Type 1 diabetes, the antibodies produced by the immune system bind to the β-cells, which then are destroyed by specialized immune cells. Because the β-cells are destroyed, no insulin is produced, and therefore, the peripheral tissues (muscle and fat) do not receive a signal that allows for glucose uptake. Ultimately, this condition causes glucose levels in the bloodstream to remain high. Individuals with Type 1 DM are dependent on exogenous (produced outside the body) sources of insulin.
Keywords: diabetes | glucose | insulin | internal regulation | pancreas | steady state | homeostasis
- Langley, L. L. (Ed.). (1973). Homeostasis: Origins of the Concept. Langley, National Library of Medicine. Stroudsburg, PA:Dowden Hutchinson, and Ross Inc.
- Sherwood, L. (1997). Human Physiology: From Cells to Systems (3rd ed.). West Publishing Co.
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