Herpes Virus Type 1 - Structure
Transcript from "Viruses," National Center for Macromolecular Imaging
With the electron microscope, the four parts of the cold sore virus, herpes virus 1, are visible. When it has a chance to invade a healthy cell, the virus behaves like the Trojan horse. Its sticky outer shell of proteins, fats and sugars tricks the cell so the cell absorbs the virus. But once inside, the virus breaks apart and its genetic poison attacks the cell's nucleus. The virus's DNA reprograms the cell's DNA. The cell's new job is to make hundreds of thousands of copies of the virus. When its work is done, the cell dies.
Additional Virus information:
Triplex, Penton and Hexon all are structural units of the capsid. The capsid of the Herpes Virus type virion is an icosohedron made of 12 pentons and 150 hexons that are surrounded and connected by triplexes.
- Chen, D. H., Jakana, J., McNab, D., Mitchell, J., Zhou, Z. H., Dougherty, M., Chiu, W. & Rixon, F. J. (2001). The pattern of tegument-capsid interaction in the herpes simplex virus type 1 virion is not influenced by the small hexon-associated protein VP26. Journal of Virology, 75(23), 11863-11867.
- Chiu, W. Viruses. National Center for Macromolecular Imaging. Houston, Tx: Baylor College of Medicine.
- Zhou, Z. H., Chen, D. H., Jakana, J., Rixon, F. J., & Chiu, W. (1999). Visualization of Tegument - Capsid Interactions and DNA in Intact Herpes Simplex Virus Type 1 Virions. Journal of Virology, 73(4), 3210-3218.
- Chiu, W. (1996). Viruses. National Center for Macromolecular Imaging. Houston, Tx: Baylor College of Medicine.
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Funded by the following grant(s)
Virus images courtesy of Wah Chiu, PhD, National Center for Macromolecular Imaging at Baylor College of Medicine. Funding for the images provided by NCMI, NIH.