Molecular Basis of Heredity: Part 3. Genetic Variation
The Molecular Basis of DNA Sequence Variations (II)
Nonsense mutations are substitution mutations that result in the substitution of a stop codon into a protein at a position where an amino acid would normally occur. Nonsense mutations result in the premature truncation of a protein. If the nonsense mutation occurs at the beginning of the gene, it may result in a complete loss of the functional capabilities provided by a protein derived from the mutated gene. If it occurs near the middle or end of the gene, it may result in the production of a protein missing only some of its functional capabilities.
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- Lewin, B. (2004). Genes VIII. Pearson Prentice Hall.
- Nussbaum, R. L., McInnes, R. R., & Willard, H. F. (2004). Thompson & Thompson: Genetics in Medicine (6th ed), revised reprint. Saunders, an imprint of Elsevier.
- National Library of Medicine. (2005). Genetics Home Reference. Retrieved 12-01-2005 from http://ghr.nlm.nih.gov/ghr/picture/Nonsense
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