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The Pathway to Genomic Medicine

Author(s): Richard A. Gibbs, PhD

HGSC Eukaryotic “Genomes” Sample Portfolio

Edited Transcript from “The Pathway to Genomic Medicine,” Richard Gibbs, PhD*
Now, since the finishing of the Human Genome Project, we’ve actually spent more time sequencing the genomes of other creatures to inform the function of human genes, than we have spent sequencing different humans in a disease context. This is a small part of the menu of all the creatures that have been pushed into this pipeline; and each one has its own story and own justification. Together, I think with the other centers and other parts of the international program, there’s probably a hundred species possessing larger genomes, extending far up the tree of life, that are well advanced in having their genomes sequenced. And of course, many more hundreds if you count microbes and small eukaryotes.

So today I’m barely going to talk about any of these. But I do like to just touch on a couple of them to give you this flavor: on the genomic side of this genome medicine equation, we’ve still got a genomic enterprise that is about sequencing the genomes of animals to help inform our direction through biomedical research via comparative genomics.

* Notes in this slide presentation are adapted from the transcript of “The Pathway to Genomic Medicine,” a presentation by Richard Gibbs, PhD, given in August 2007, as part of Baylor College of Medicine’s Department of Medicine Grand Rounds Human Genetics Symposium.