Eating in Space: Does Nutrition Matter?
Muscle Wasting Bed Rest Studies
Two key projects of the NSBRI Nutrition, Physical Fitness and Rehabilitation Team are working to develop countermeasures against loss of muscle mass and strength. The first, our cornerstone bed rest study (with bed rest being an important earth-based model for some of the physiological changes occurring in space), tests the effect of a supplement containing essential amino acids. Dr. Robert Wolfe, currently at the University of Arkansas Medical School, is the principal investigator. The second project uses the same protocol as the Wolfe bed rest study so that results from both projects can be compared. But this second study, done at Tufts University, with Dr. Carmen Castaneda-Sceppa as Principal Investigator, adds an exercise component and a third component, which optimizes the timing between supplement ingestion and exercise.
- Castaneda, C., Cloutier, G., Cadena, S., Pearlman, J., Brooks, N., Layne, J., Roubenoff, R. (2006). Resistance training and timed amino acid supplementation protects against the loss of muscle mass and strength with disuse. FASEB, 20, A591.
- Paddon-Jones, D., Sheffield-Moore, M., Urban, E. J., Sanford, A. P., Aarsland, A., Wolfe, R.R., Ferrando, A.A. (2004). Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest. J Clin Endocrinol Metab, 89, 4351-4358.
- Leg exercise. Dr. Carmen Castenade-Sceppa Study: Time feeding and resistance training to prevent muscle atrophy. Prepared by Gregory Cloutier.
Your slide tray is being processed.
Funded by the following grant(s)
This work was supported by National Space Biomedical Research Institute through NASA cooperative agreement NCC 9-58.