Eating in Space: Does Nutrition Matter?
Changes in Muscle After 28 Days Bed Rest (kg)
This slide shows the effect of adding the essential amino acid supplement to the diet on leg muscle mass, and the loss of muscle strength as a result of the 28 days of bed rest. Results from the supplemented group are shown in yellow; results from the placebo group are shown in orange. The graph on the left illustrates the loss of approximately 400 g of leg muscle mass in the placebo group. In contrast, those supplemented with essential amino acids actually gained about 200 g of leg muscle mass.
Loss of leg strength after bed rest is represented by the graph on the right. Again, the amino acid-supplemented group is shown in yellow and the placebo group in orange. Both groups lost muscle strength, although the loss was somewhat ameliorated in the amino acid supplemented group.
- Paddon-Jones, D., Sheffield-Moore, M., Urban, E. J., Sanford, A. P., Aarsland, A., Wolfe, R.R., Ferrando, A.A. (2004). Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest. J Clin Endocrinol Metab, 89, 4351-4358. Redrawn.
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Funded by the following grant(s)
This work was supported by National Space Biomedical Research Institute through NASA cooperative agreement NCC 9-58.